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周宏伟


发布日期:2016年04月04日

 

           

                                                                                                         

1、基本信息

 

姓名:周宏伟

职称:教授

电话:0573-83642057

Email: zhouhw@zju.edu.cn

通讯地址: 浙江省嘉兴市2020欧洲杯竞彩平台梁林校区1-131

 

2、个人经历:

 

1976年生。2001年毕业于湖南大学化学化工学院应用化学专业,获硕士学位。20041月毕业于浙江大学化学系有机化学专业,获博士学位。2004-2005于加拿大McMaster大学从事博士后研究。20057月年被浙江大学聘为副教授,2010年被认定为浙江大学“求是青年学者”,2011年被遴选为博士生导师。2015年加入2020欧洲杯竞彩平台,被聘为制药工程学科带头人、学术委员会委员,2016年任生化学院副院长。主持国家自然科学基金青年项目、面上项目、浙江省杰出青年基金项目等省部级以上项目多项。在国际著名期刊上发表研究论文五十余篇,独立指导博士生3名,硕士生12名。

 

3、研究方向

 

1. 有机合成化学

2. 药物合成化学

 

4、主持科研项目

1)萘普生合成新工艺研究

重点应用技术项目,No. 005180302018.1-2021.12
2)杂原子参与的炔丙-联烯重排促进的分子内协同反应研究

浙江省自然科学基金, No. LY14B020008 2015.1-2017.12

3. 硫参与成环反应

国家自然科学基金,No209721342010-2013

4. 镓参与的有机合成反应

国家自然科学基金,No207020462008-2010

5. 卡宾参与的有机金属试剂的合成及其在有机合成中的应用研究

教育部归国留学基金,J20060128  2006-2007

6. 卡宾参与金属有机化合物的制备以及其应用研究

浙江省人才专项(浙江省杰出青年基金), R405066 2006-2008

 

5、教学工作

 

1. 本科教学:有机化学,药物化学

2. 研究生教学:有机合成化学

 

6、荣誉奖励

 

2010年,浙江大学求是青年学者

2012年,浙江大学理学部第二届青年教师本科教学奖

 

7、代表性成果:(代表性研究论文、专著和专利)

2018

Stereoselective and Regioselective 5-exo-dig Cyclization of 8-Alkynylnaphthalen-1-amine for the Synthesis of (E)-2-(arylthio) alkylene)-1,2-dihydrobenzo[cd]indole

Cheng Bi, Lianpeng Zhang,* Guanyinsheng Qiu, Xiaofang Li, Jinzhong Yao and Hongwei Zhou*

Org. Biomol. Chem., 2018, 16, 3006-3011.

 

Synthesis of α-Methylene-β-lactams Enabled by Base-Promoted Intramolecular 1,2-Addition of N-Propiolamide and C–C Bond Migrating Cleavage of Aziridine

Lianpeng Zhang, * Lele Ma, Hongwei Zhou,* Jinzhong Yao, Xiaofang Li, and Guanyinsheng Qiu*

Org. Lett.201820, 2407–2411

 

Ratiometric fluorescent and colorimetric BODIPY-based sensor for zinc ions in solution and living cells

Shuai Xia, Jinjin Shen, Jianbo Wang,? Hailong Wang, Mingxi Fang, Hongwei Zhou,? Marina Tanasova,?

Sensors and Actuators B 2018, 258, 1279–1286.

 

Aromatic Pummerer reaction for the remote para- or ortho-benzyl nucleophilic functionalization 

Xingping Bao, Guangyu, Xu, Jinzhong, Yao, Hongwei Zhou*

Org. Chem. Front., 2018, 6, 1019-1021

 

2017年:

Nucleophilic Functionalizations of Aniline Derivatives: Aromatic Pummerer Reaction for Umpolung Halogenation and Hydroxylation on Benzene Ring

Xingping Bao, Jinzhong Yao, Hongwei Zhou,* and Guangyu Xu*

Org. Lett.201719, 5780-5782

 

A colorimetric quinoline-based chemosensor for sequential detection of copper ion and cyanide anions

Chenjun Wu, Jianbo Wang*, Jinjin Shen, Chenyu Zhang, Zuoyi Wu, Hongwei Zhou*

Tetrahedron 2017, 73, 5715-5719

 

Synthesis of benzothiophene and indole derivatives through metal-free propargyl-allene rearrangement and allyl migration

Jinzhong Yao*, Yajie Xie, Lianpeng Zhang, Yujin Li and Hongwei Zhou*

Beilstein J. Org. Chem. 2017, 13, 1866–1870

 

Construction of Polysubstituted 1,2-Dihydrocyclobuta[b]naphthalenes and 1,2-Dihydrocyclobuta[b]anthracenes with Photoluminescence

Dianpeng Chen, Lianpeng Zhang,* Jinzhong Yao, and Hongwei Zhou,*

J. Org. Chem. 2017, 82, 6202?6209

Synthesis of benzil-o-carboxylate derivatives and isocoumarins through neighboring ester-participating bromocyclizations of o-alkynylbenzoates

Si-Tian Yuan, Hongwei Zhou, * Lianpeng Zhang, Jin-Biao Liu* and Guanyinsheng Qiu *

Org. Biomol. Chem., 2017, 15, 4867–4874

 

CuX-Activated NHalosuccinimide: Synthesis of 3Haloquinolines via 2 Electrophilic Cyclization of Alkynyl Imines

Le Liu, Dianpeng Chen, Jinzhong Yao, Qianshou Zong,* Jianbo Wang, and Hongwei Zhou*

J. Org. Chem. 2017, 82, 4625-4630..

 

Applicable β-sulfonium carbanions: facile construction of thiophene derivatives

Dianpeng Chen, Gangdong Xing, Jinzhong Yao* and Hongwei Zhou*

Org. Chem. Front. 2017, 4, 1042-1045.

 

KBr/K2S2O8-mediated dibromohydration of N-(2-alkynylaryl)acetamide

Guanyinsheng Qiu,* Yuewen Li, Lele Ma and Hongwei Zhou*

Org. Chem. Front. 2017, 4, 1069-1073.

 

Coumarin-based Hg2+fluorescent probe: Synthesis and turn-onfluorescence detection in neat aqueous solution

Chenjun Wu, Jianbo Wang?, Jinjin Shen, Cheng Bi, Hongwei Zhou*

Sensors and Actuators B, 2017, 243, 678–683.

 

2016年:

One-Pot Synthesis of Tetraphene and Construction of Expanded Conjugated Aromatics.

Wang, Jianbo, Wang, Jinzhong, Yao, Hailong, Wang, Hao, Chen, Jingcheng, Dong and Hongwei, Zhou *

J. Org. Chem. 2016, 81, 5250-5255.

 

Acetyl Bromide Promoted Sequence via Allene Intermediates: Metal-Free Construction of 2,3-Dihydroindenes and Isoindolines

Le, Liu, Jinzhong, Yao, Dianpeng Chen and Hongwei Zhou*

Adv. Synth. Catal. 2016, 358, 2671-2677

 

Construction of highly functionalized naphthalenes using an in situ ene–allene strategy

Dianpeng Chen, Gangdong Xing, Jinzhong Yao* and Hongwei Zhou*

RSC Adv., 2016, 6, 103320

 

Construction of highly functionalized thiophene and benzo[b] thiophene derivatives via a sequence of propargyl–allenyl isomerization/cyclization/demethylation 

Dianpeng Chen, Gangdong Xing, Xueyuan Chen, Jinzhong Yao* and Hongwei Zhou*

Tetrahedron Lett. 2016, 57, 5124.

 

2015年:

1. Selectfluor-Promoted Sequential Reactions via Allene Intermediates: Metal-Free Construction of Fused Polycyclic Skeletons

Le Liu, Jianbo Wang, and Hongwei Zhou*,

J. Org. Chem. 2015, 80, 4749?4752

 

2. From Acyliminiums/Amidoallenyliums to Highly Functionalized Allene Intermediates: Stereoselective Preparation of Z-Amidovinyl-Furans, -Pyrroles, -Thiophenes, -Benzofurans and -Benzothiophenes

Le Liu, Dianpeng Chen, and Hongwei Zhou*

Adv. Synth. Catal. 2015, 357, 389-394

 

3. Sulfone promoted Rh(III)-catalyzed C–H activation and base assisted 1,5-H shift strategy for the construction of seven-membered rings

Dianpeng Chen, Gangdong Xing and Hongwei Zhou*

Org. Chem. Front., 2015, 2,947.

 

4. Metal-free synthesis of polyfunctionalized 2,3-dihydropyrroles and furans via the sequence of propargyl–allenyl isomerization and Alder ene reaction

Gangdong Xing, Sikai Chen, Chunxin Lu* and Hongwei Zhou*

Tetrahedron Lett.  2015, 56, 11381140.

 

2014 and before

 

5. Thionium ion promoted Michael acceptor: a sequence of Pummerer/Michael reactions for the stereoselective synthesis of 5-(1-(arylthio)vinyl)-oxazolines
Shimin Xu, Qianyun Zhang, Hongwei Zhou*

Tetrahedron Lett. 2014, 55, 1196.

 

6. Propargyl–Allenyl Isomerizations and Electrocyclizations for the Functionalization of Phosphonium Salts: One-Pot Synthesis of Polysubstituted Vinylbenzenes and Naphthalenes
Guoqing Zhao, Qianyun Zhang, and Hongwei Zhou*
Adv. Synth. Catal. 2013, 355, 3492.

 

7.Silver carboxylate promoted lactonization: a general method applicable to prepare medium and large-sized lactones without high dilution or slow addition
Le Liu, Shimin Xu, Hongwei Zhou*
Tetrahedron 2013, 69, 8386.

 

8. Synthesis of Polyfunctionalized Quinolines via the Sequence of Propargyl–Allenyl Isomerization and Aza-electrocyclization

Hongwei Zhou*, Le Liu, and Shimin Xu
J. Org. Chem., 2012, 77, 9418.

 

9. Applications of the in situ Propargyl-Allenyl Isomerization in Organic Synthesis

Yanpeng Xing, Yuxiu Wei, Hongwei Zhou*

Curr. Org. Chem. 2012, 16, 1594 (invited review).

 

10. Sulfur as a Bridge: Synthesis of Medium Rings via a Bicyclic Sulfonium Ion

Hongwei Zhou,* Yanpeng Xing, Le Liu, and Junjie Hong

Adv. Synth. Catal. 2011, 353, 3146.

 

11. A Simple and Efficient Protocol to 1,2,4-Substituted Pyrroles via a Sonogashira Coupling–Acid-Catalyzed Cyclization

Da Zhu, Jie Zhao, Yuxiu Wei, Hongwei Zhou*

Synlett 2011, 2185.

 

12. Heteroatom as a Promotor: Synthesis of Polyfunctionalized Benzenes and Naphthalenes

Hongwei Zhou,* Yanpeng Xing, Jinzhong Yao, and Yun Lu

J. Org. Chem. 2011,76, 4582.

 

13. Sulfur-assisted propargyl–allenyl isomerizations and intramolecular cyclization for the synthesis of tricyclic thiophene derivatives

Guangyu Xu , Kaixiong Chen , Hongwei Zhou *

Tetrahedron Lett. 2010, 51, 6240.

 

14.Sulfur-Assisted and 1,8-DiazabicycloACHTUNGTRENUNG[5.4.0]undec-7-ene (DBU)-Catalyzed Cyclization of 2-Alkynylanilines for the Metal-Free Synthesis of Indole Derivatives

Hongwei Zhou,* Da Zhu, Yanpeng Xing, and Huafeng Huang

Adv. Synth. Catal. 2010, 352, 2127.

 

15. Sulfur-Assisted Propargyl-Allenyl Isomerizations and Electrocyclizations for the Convenient and Efficient Synthesis of Polyfunctionalized Benzenes and Naphthalenes

Hongwei Zhou,* Yanpeng Xing, Jinzhong Yao, and Junhui Chen

Org. Lett., 2010, 12, 3674.

 

16.Ga(OTf)3-Promoted Sequential Reactions via Sulfur-Assisted Propargyl-Allenyl Isomerizations and Intramolecular [4 ? 2] Cycloaddition for the Synthesis of 1,3-Dihydrobenzo[c]thiophenes
Hongwei Zhou,* Da Zhu, Yongfa Xie, Huafeng Huang, Kai Wang
J. Org. Chem. 2010, 75, 2706.

 
17. Sulfur-Assisted Five-Cascade Sequential Reactions for the Convenient and
Efficient Synthesis of Allyl Thiophen-2-yl Acetates, Propionates, and Ketones
Hongwei Zhou,* Yongfa Xie, Lianjun Ren, and Rui Su
Org. Lett. 2010,12, 356.

 
18.Sulfur-Participated Nazarov-Type Cyclization: A Simple and Efficient Synthesis for 3-Thio-1H-indenes
Hongwei Zhou*, Yongfa Xie, Lianjun Ren, Kai Wang
Adv. Synth. Catal. 2009, 351, 1289.

 
19.‘Long-Range’ Pummerer-Type Cyclization: A Simple and Facile Synthesis of 5-Vinyl-1,3-oxazole
Guanyu Xu, Kaixiong Chen, Hongwei Zhou*
Synthesis2009, 21, 3565.

 
20.Electrophilic cyclization of 4-thio-but-2-yn-1-ols via 1,2-migration of
the thio group: efficient synthesis of 2,4-dihalo-3-thio-substituted furans
Hongwei Zhou,* Jinzhong Yao, Guoliang Liu
Tetrahedron Lett. 2008, 49, 226–228.


21 Bismetalated carbon for tandem Wittig-type reaction via allylgallation of magnesium acetylides: A convenient and efficient method to allyl allenes
Hongwei Zhou,* Guoliang Liu, Changying Zeng
J. Orgmet. Chem. 2008, 787–791.

 
22. GaCl3-Catalyzed Chloroacylation of Alkynes: A Simple, Convenient and
Efficient Method to b-Chlorovinyl Ketones
Hongwei Zhou,* Changying Zeng, Lianjun Ren,Wenhui Liao, Xian Huang*
Synlett 2006, 3504.

 

23. A New Thermal Source of Dimethoxycarbene. Dipolar Intermediates Lead to 2:1
Stoichiometry in Reaction with Electrophilic Alkenes
Hongwei Zhou, Grzegorz Mloston and John Warkentin*
Org. Lett. 2005, 7, 487.


24. Facile and Effective Copper-Mediated Cyclization Reaction of Cyclopropylideneacetic
Acids (or Esters) and Cyclopropylideneacetonitriles
Xian Huang* , Hongwei Zhou, Wanli Chen
J. Org. Chem. 2004, 69, 839.

 
25.First Tandem Free-Radical Cyclization Reaction of Alkylenecyclopropanes: A Novel and Efficient Method for the Preparation of 2-(3,4-Dihydronaphthalen-2-yl)malonic Acid Diethyl Esters.
Hongwei Zhou, Xian Huang*, Wanli Chen
J. Org. Chem. 2004, 69, 5471


26.An Efficient Access to Selenazoline-4-Carboxylate Derivatives Incorporating Cyclopropyl Groups
Xian Huang *, Wan Li Chen, Hongwei Zhou
Synlett 2004, 329


27.A Novel One-Pot Stereoselective Synthesis of N-[(E)-Homocinnamyl] Amides
Wanli Chen, Xian Huang*, Hongwei Zhou
Synthesis 2004, 1573


28.CuX2Mediated Halogenation of Alkylidenecyclopropanes: A Highly Efficient and Stereoselective Method for the Preparation of 3-Halo-homoallylic Halides
Hongwei Zhou, Xian Huang*, Wanli Chen
Synlett 2003, 13, 2080


29.Novel Tunable CuX2-Mediated Cyclization Reaction of Cyclopropylideneacetic Acids and Esters for the Facile Synthesis of 4-Halomethyl-2 (5H)-furanones and 4-Halo-5,6-dihydro-2H-pyran-2-ones.
Xian Huang* and Hongwei Zhou
Org. Lett. 2002, 4, 4419

 

8、社会兼职

 

1). 国家自然科学基金委、教育部留学回国基金委、浙江省自然科学基金委、北京市自然科学基金委、山东省自然科学基金委、江苏省自然科学基金委、黑龙江省自然科学基金委通讯评审专家

2). 中国化学会会员、嘉兴市化学化工学会理事

3)嘉兴市科技局副局长(挂职)

 

 

 

2020欧洲杯竞彩平台-外围盘口下注官网  地址:浙江省嘉兴市嘉杭路118号
电话:0573-83643264  

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